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    E van de Kamp Irini Saridakis Cytokines and their receptors are expressed in the brain. They interact closely with neurohormones and neurotransmitters. They stimulate neovascularization and gliosis. In animal models, they affect behaviors such as food intake, temperature regulation, and social exploration. In addition to immunologists and neuroscientists, psychiatrists also got interested. The book Cytokines, Stress, and Depression is devoted to the establishment of a link between cytokines and clinical depression.

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    It is based on the proceedings of a meeting that took place in Roscoff, France, on May 14—17, The evidence for a cytokine connection in depressive illness as presented in this book is at first glance overwhelming: cytokines are associated with vegetative signs of depression such as sleep and appetite disturbances; treatment with cytokines produces depressed mood and altered cognition; cytokine production is affected by stress; cytokines are associated with increased activity of the hypothalamic-pituitary-adrenal axis and dysregulation of neurotransmitter metabolism, including norepinephrine and serotonin; antidepressant treatment affects cytokine secretion; and so on.

    Not so fast! The hypothesis, no matter how attractive, remains a hypothesis. The evidence is mostly circumstantial. Direct evidence of cytokine dysregulation in major depression, presented in section 1 of the book, remains slim and suffers from methodological flaws that have not been easy to fix.

    Book Advances In Medicine And Biology Volume 20 2011

    Unreplicated, even contradictory findings still abound. Treatment protocols have not yet been developed. The obstacles facing the cytokine hypothesis of depression should not necessarily diminish the scientific value of this book. The editors have done an excellent job in writing the recipe.

    The different authors have made a commendable effort in preparing the ingredients. The proof, as they say, is in the pudding. Forgot Username?

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